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IEEE MTT-S Technical Committee MTT-10
Biological Effect and Medical Applications of RF and Microwave

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2013 1EEE MTT-S International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-Bio 2013)

IMWS-Bio 2013 was held in Singapore on December 9-11, 2013.

Website: http://www.imws2013.org/

                                                                Program download

Keynote speakers

•   Prof Nitish V. Thakor, National University of Singapore, Singapore/ Johns Hopkins University, USA,"Frontiers of Implantable Neuro Technologies: from Nerve to Brain to Brain Machine Interface"

•   Prof Gianluca Lazzi, University of Utah, USA, "Advances and Challenges in Bioelectromagnetics for Implantable Devices: Current and Future Applications"

•   Prof Hoi-Jun Yoo, KAIST, Korea, "WBAN Circuits and Systems"

•   Dr Dennis L. Polla, IARPA, USA, "Integrated BioMEMS"

•   Prof Yahya Rahmat-Samii, UCLA, USA, "Bio-Telemetry Creating an Exciting Paradigm in Modern Healthcare System: Medical Monitoring and Diagnostics using Ingestible Capsules"

•   Prof Niels Kuster, Foundation for Research on Information Technologies in Society (IT’IS), 8004 Zurich, Switzerland and Swiss Federal Institute of Technology (ETH) Zurich, "In Silico Effectiveness and Safety Evaluations of Active Implantable Neuro-Stimulating Devices: Still A Dream or Soon Reality"

•   Prof John L. Volakis, The Ohio State University, USA , "Biomedical Sensors for Imaging and Neurological Monitoring"

•   Prof J.C. Chiao, University of Texas at Arlington, USA, "Implantable Wireless Medical Devices and Systems” (IEEE MTT-S DML)

Invited speakers

•        Dr Amin Abbosh, The University of Queensland, Australia, “Microwave System for Head Imaging- Challenges and recent developments”

•        Prof Franklin Bien, Ulsan National Institute of Science and Technology, Korea, “Wireless Power Transfer Technologies for Medical Implantable Devices”

•        Prof Dau-Chyrh Chang, Oriental Institute of Technology, Taiwan, "Tradeoff study of microwave imaging for biomedical application"

•        Prof Joseph Chang, Nanyang Technology University, Singapore , "Fully-Additive Printed RFID on plastic films"

•        Prof Hsien-Chin Chiu, Chang Gung University, Taiwan, "GaN on Si MMICs for wireless charged Smart Cloth Applications"

•        Dr Eric Chow, Cyberonics Inc., Houston, USA, "Commercial Development of RF Medical Implantable Devices"

•        Prof Tiejun Cui, Southeast University, China, "Microwave and THz Surface Plasmons on Ultrathin Corrugated Metal Structures "

•        Prof Schreurs Dominique, Katholieke Universiteit Leuven, Belgium, "Radar-Based Health Monitoring"

•        Prof Yun-Seong Eo, Kwangwoon University, Korea, "A fully integrated 3 ~ 5 GHz UWB RF Transceiver for WBAN applications"

•        Prof Karu Esselle, Macquarie University, Australia, "Making a Telemetry System Implantable: Challenges and Opportunities in Antenna Design"

•        Dr Joonho Gil, RadioPulse Inc., Korea, "A Fully-Integrated Low-Power High-Coexistence 2.4-GHz ZigBee Transceiver for Biomedical Applications"

•        Prof Chris Hancock, Bangor University, UK, "A NewWave in Electrosurgery–Therapeutic Applications of Microwave/RF Energy and Novel Antenna Structures"

•        Prof James C. M. Hwang, Air Force Office of Scientific Research, USA, "Broadband Microchamber for Electrical Detection of Live and Dead Biological Cells"

•        Prof Koichi Ito, Chiba University, Japan, "Physical Human Phantoms for Evaluation of Implantable Antennas"

•        Dr Mikhail kozlov, Max Plank Institute for Human Cognitive and Brain Sciences, Germany, "Simulation-driven design and optimization of MRI array"

•        Prof Vincent Lee, National University of Singapore, Singapore, "MEMS based enabling technologies for self-sustained wireless sensor nodes"

•        Prof Joshua Le-Wei Li, University of Electronic Science and Technology of China, China; and Monash University, Malaysia/Australia, "Microwave Near-Field Effects and Characterizations for Noninvasive Breast Cancer Treatment"

•        Prof Shufang Li, Beijing University of Posts and Telecommunications, “Electromagnetic radiation-physiological indexes relation evaluating system”

•        Prof Fujiang Lin, University of Science and Technology of China, "Millimeter Wave therapy and needless accupunture study in USTC"

•        Prof Jenshan Lin, University of Florida, USA, "Micro-Radar Sensors for Noninvasive and Noncontact Detection of Vital Signs for Human and Animal Healthcare"

•        Prof Qinghuo Liu, Duke University, USA, "Progress and Computational Challenges in Microwave Imaging and Microwave Induced Thermoacoustic Tomography "

•        Prof Ai Qun Liu, Nanyang Technological University, Singapore, "Tunable Metamaterials and Optofluidic Transmission Optics"

•        Prof Thoralf Niendorf, Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany, "Multi-Channel Transmit/Receive RF Coil Arrays for Magnetic Resonance Imaging at Ultrahigh Fields: Design, Validation and Clinical Application"

•        Prof Koichi Ogawa, Toyama University, Japan, "BAN Over-the-Air Testing Using an Arm-Swinging Dynamic Phantom"

•        Prof Mikael Persson, Chalmers University of Technology, Sweden, "Microwave based diagnostics and treatment in practice"

•        Prof Ada Poon, Stanford University, USA, "Emerging wireless applications in biomedicine"

•        Prof Atif Shamim, King Abdullah University Of Science & Technology (KAUST), KSA, "Implantable Intraocular Pressure Monitoring Systems: Design Considerations"

•        Dr Thomas Ussmueller, Universität Erlangen-Nürnberg, Germany, "Remote powered medical implants"

•        Prof Thomas Vaughan, University of Minnesota, USA,

•        Prof Zhigong Wang, Southeast University, China, "Neural Signal Regeneration and Motor Function Rebuilding of Paralyzed Limbs Based on Principles of Communication Incorporated with Microwave Transmission System"

•        Prof Zhihua Wang, Tsinghua University, China, "Wireless intelligent sensor used to the life time tracing of the pathological features by sounds monitoring"

•        Prof Hao Xin, University of Arizona, USA, "Thermoacoustic Imaging and Spectroscopy for Biomedical Applications"

•        Prof Hao Yang, Queen Mary, University of London, United Kingdom, "Body-centric Wireless Communications for Healthcare Applications"

•        Prof Mehmet R. Yuce, Monash University, Australia, "Wireless Body Sensors: Design and Implementation"

•        Prof Ke-Qin Zhang, Soochow University, China, “Silk Fibroin Based Flexible Photovoltaic Devices"

•        Prof Yuanjin Zheng, Nanyang Technological University, Singapore,” Microwave-acoustic correlated imaging and circuit modelling of biological tissues”

2013 International Microwave Symposium

 

Workshop

Room:

1300 Monday, June 3, 2013

Session: WMF

Electro-Nanoporation: An Emerging Biomedical Electromagnetic Application

Chair:

Guglielmo d'Inzeo, La Sapienza University of Rome

Co-Chair:

James C. M. Hwang , Lehigh University

Short (i.e. from nanoseconds to microseconds) and intense (amplitudes in the megavolt-per- meter range) pulsed electric fields (ms/ns PEFs) have shown different and useful effects on biological systems, with important applications in biology and medicine. Promising results have been reported, e.g., in gene transfer techniques, enhancing gene delivery to the cell nucleus and inducing cancer treatment with complete melanoma remission observed in vivo. nsPEFs have also been tested for neuromuscular, neurophysiological and cardiac stimulation. In these cases the pulses can activate alternative cardiac pacing, defibrillation and relief of chronic pain. Further, nsPEFs seem to accelerate platelet aggregation in vitro, thereby promoting wound healing. These bio-effects mediated by functional and structural cell and sub-cellular membrane modifications are considered one of the most exciting results of the interaction between electromagnetic fields and living matters. To deliver short nsPEFs to biological systems (e.g. cells, tissues or small animals) and to accurately characterize the resulting effects, it is important that the intended pulse waveform is well preserved within the biological target. For this reason, nanopulse generators capable of rapid delivery of high voltage have to be combined with proper applicators having an optimum impedance matching. The generator miniaturization, the delivery of high voltage with very small (i.e., down to hundred of ps) rise and fall times, as well as the impedance matching with different exposure setups in a broad frequency band are challenging issues for the scientific community. Another stimulating aspect involves understanding the dynamic interactions between pulsed electromagnetic energy and biological targets down to the different intracellular structures. In this context, molecular dynamics simulations seem the preferred modeling methodology, which can perform virtual experiment useful for the definition of nsPEF action mechanisms at the molecular level or above. Another impact on the activities of the IMS community can came from the design of different kinds of applicators and exposure systems both in vitro and in vivo. The wide application possibilities, as well as the open modeling and technological challenges, constitute an emerging and intriguing field of research. Therefore, this workshop is an interesting opportunity for the IMS community to gain insight into this new scientific area. The workshop will cover state of the art of the research on nsPEFs, including generator design and assembly, electrode layout, micro-chamber development, modeling and simulation, as well as recent medical applications. The final aim is to give new perspectives and to promote the involvement of the IMS community in the nsPEF research for biomedicine.

WMF-1

Electroporation of Organelles
by Intense Nanosecond Electric Pulses: From Theory Towards Applications

1300-1345

M. Reberšek, D. Miklavčič, University of Ljubljana, Ljubljana, Slovenia

 

Theoretical prediction and recent studies of organelle poration by intense nanosecond pulses has shown that only on extreme conditions internal membranes could be porated without affecting the plasma membrane. A lot of work has been done on different concept of nanosecond high-voltage pulse generation. Recent studies have shown that the method might be used for cancer treatment, delivery of active substances to treated cells, and water and food pasteurization.

WMF-2

Dose Response in Nanosecond Bioelectrics

1345-1430

P. Vernier, Old Dominion University, Norfolk, United States

 

Evaluating biological responses to nanosecond pulsed electric fields requires attention to metrological issues as well as the bioelectrical environment. We discuss the range and possible values of the variables that determine the delivered dose of electrical energy, including pulse amplitude and duration, pulse repetition rate and delivery pattern, and pulse waveform and spectral content. Molecular and continuum modeling in the nanosecond bioelectrical regime is also considered.

WMF-3

Design and Characterization of Optimally Matched Planar Micro- Chambers for Nanosecond Electroporation of Biological Cells

1430-1515

C. Palego1, C. Merla1, Y. Ning1, C. Multari1,2, X. Cheng1,2, J. C. Hwang1, 1Lehigh University, Bethlehem, United States, 2Lehigh University, Bethlehem, United States

 

This talk explores the development of a planar microchamber for detection and manipulation of biological cells using nanosecond electric pulses. The microchamber is formed between a gold coplanar stripline on a microscope slide and a poly-dimethyl-siloxane (PDMS) microchannel cap. The microchannel delivers single cells and minimizes the attenuation by culture media. The device insures broadband impedance match throughout cell delivery and sensing while allowing simultaneous optical microscopy.

WMF-4

Modeling Interaction of Nanosecond Pulsed Electric Fields with Biological Systems: From Cells to Molecules

1515-1600

M. Liberti1, F. Apollonio1, G. d'Inzeo1, C. Merla2, 1Sapienza University of Rome, Rome, Italy, 2ENEA, Rome, Italy

 

Nanosecond pulsed electric field (nsPEF) affects cell structure and physiology leading to potential biomedical applications. E field induced by nsPEF within the cell membrane (microdosimetry) drives its poration . Hence, accurate microdosimetric models are presented. To comprehend the nanopulses action at molecular level molecular dynamics (MD) simulations are necessary. MD development and coupling with microdosimetric models are described, as well the underlying mechanisms for pore formation.

Workshop

Room:

0800 Friday, June 7, 2013

Session: WFC

Microwave Sensors and Biochips for Biomolecules and Cells Characterization

Chair:

Katia Grenier, LAAS-CNRS

Co-Chair:

Arnaud Pothier, XLIM-CNRS

This workshop addresses the latest advances on the microwave, millimeter and sub millimeter wave biosensing and probing instrumentations suitable for biomolecules, single cell, cells suspensions and even tissues investigations at the microscale. Accurate biological samples characterizations and analysis will be highlighted with resonant or broadband approaches with respect to the targeted applications, which refer to early diseases diagnostic and prognostic notably and especially toward cancer fight. This workshop will also benefit from a special talk dedicated to microfluidic and lab-on-a-chip developments, which will establish the current requirements of lab-on-a-chip approaches. A large place for discussion and interactions between speakers and attendees will be kept all along the day.

WFC-1

Microfluidics for POC diagnostics applications

0800-0900

E. S. Fu, University of Washington, Seattle, United States

 

This presentation will focus on the role of microfluidics-based technology in point-of-care (POC) diagnostics development with an emphasis on recent advances to address the challenges of lower-resource settings.

WFC-2

Broadband Permittivity Measurements of Fluids, Biomolecules and Cell Suspensions using Microfluidic Structures with Integrated, On-Chip Calibration Structures

0900-0945

J. C. Booth1, Y. Wang1, A. Padilla1,3, N. D. Orloff2, J. Mateu3, C. Collado3, E. Rocas3, 1NIST, Boulder, United States, 2NIST, Gaithersburg, United States, 3Universitet Polytecnica de Catalunya, Barcelona, Spain

 

We present on-wafer, calibrated microwave measurements of nanoliter fluid volumes by use of planar devices integrated with microfluidic channels. To improve the accuracy of such measurements, calibration structures are integrated on-chip along with the microchannel-loaded planar devices. We discuss calibration of such microfluidic devices, and also explicitly address effects due to electrode polarization for measurements of conducting fluids.

WFC-3

Microwave Interferometers for the Measurement of Single Yeast Cells and Particles in DI Water

0945-1030

P. Wang, Clemson University, Clemson, United States

 

Electronic detection and analysis of single cells and particles in liquid is promising for developing low-cost and high-performance biomedical instruments and devices, which have the potential for rapid diagnostic test applications in clinics and at home. Nevertheless, such measurements at microwave frequencies have been difficult. This presentation focuses on recent results on ultra-sensitive microwave interferometers for single cell and single particle detection and characterization in liquid.

WFC-4

Non-Invasive and Broadband Analysis of Living Cancer Cells in their Culture Medium with Microwave-Based Biosensors

1030-1115

K. Grenier1, D. Dubuc1, T. Chen1, F. Artis1, M. Poupot2, J. Fournie2, 1Laas-CNRS, Toulouse, France, 2CRCT, Toulouse, France

 

Due to the convergence of microtechnologies, microwave and millimeter wave sensing at the molecular and cellular levels is now accessible. It permits to provide to the biomedical community a new way to observe the living, in complementarity with existing techniques. Given this framework, the presentation will focus on the development of microwave and millimeter wave biosensors for the broadband analysis of biomolecules and living cancer cells in their traditional culture medium.

WFC-5

Silicon Biochips for Broadband Microwave and Millimeter-Wave Cell Characterization

1115-1200

D. Kissinger, University of Erlangen-Nuremberg, Erlangen, Germany

 

High-performance SiGe is the technology of choice for the realization of complex broadband integrated sensors at low manufacturing costs. This enables the realization of highly miniaturized sensor systems for dielectric characterization of various biological substances and suspension with potential applications in future point-of-care diagnosis. This presentation focuses on recent results in the area of broadband microwave and millimeter-wave integrated front-ends for spectroscopic biosensors.

WFC-6

Microwave-to-Terahertz Near–Field Methods for the Assessment of Biological Systems

1200-1245

N. Klein, Imperial College London, London, United Kingdom

 

The microwave- to terahertz frequency range is of great interest for the assessment of biological systems based on precise measurements of subtle changes of the relaxation of water, which is induced by dissolved / dispersed proteins or cells. Broadband and resonator methods comprising high Q factors and small interaction volumes will be presented. Examples of measurements on dissolved proteins and blood cells will underline the potential for free-solution and label free biosensor applications.

WFC-7

Microwave Biosensors for Label-Free Characterization of Single Cells

1245-1330

G. E. Bridges1, M. Nikolic-Jaric1, E. Salimi1, T. Cabel1, A. Bhidea1, K. Braasch2, M. Butler2, D. J. Thomson1, 1University of Manitoba, Winnipeg, Canada, 2University of Manitoba, Winnipeg, Canada

 

By combining microwave detection with dielectrophoresis-induced actuation we show how to build a very sensitive microfluidic single cell biosensor, capable of sensing small changes in intracellular electrical properties, and subtle enough to differentiate viable and apoptotic cell states. High-intensity pulsed electric fields can be applied to cells in this system, temporarily or permanently electroporating the cell membrane, providing a tool for single cell modification and analysis.

WFC-8

Microwave Resonant Biosensors for Cancer Cell Maturity and Aggressiveness Discrimination

1330-1415

A. Pothier1, L. Zhang1, A. Landoulsi1, C. Dalmay1, P. Blondy1, A. Lacroix2, F. Lalloue2, S. Battu2, M. Jauberteau2, C. Morand Du Puch3, C. Lautrette3, 1XLIM Institute, Limoges, United States, 2Homéostasie Cellulaire et Pathologies, Limoges, France,3Oncomedics, Limoges, France

 

This talk will show the potential of high frequency dielectric spectroscopy for biological cell analysis Proposed method is based on resonant micro-sensors operating at microwave frequencies to allow extracting intracellular dielectric properties up to unique cell. It will be showed that such measurement can be relied on the cell aggressiveness or on the cell immaturity.

WFC-9

High-Resolution Micromachined Millimeter-Wave Near-Field Imaging Sensors For
Biomedical Applications

1415-1500

J. Oberhammer, KTH Royal Institute of Technology, Stockholm, Sweden

 

Cancer tissue has a higher water content than healthy tissue which results in a significantly different microwave signature. This lecture reports on near-field millimeter-wave measurements for medical diagnosis, in particular on a high-resolution, micromachined microwave probe for skin cancer diagnosis. Tissue and skin modelling, as well as characterization data and calibration procedures are presented.

WFC-10

Scanning Microwave Microscope for Nano-scale Microwave Characterization

H. Tanbakuchi, Agilent Technologies, Santa Rosa, United States

 

Scanning Microwave Microscope for Nano-scale Microwave Characterization

 

 

Workshop

 RFIC Conference

Room:

1300 Sunday, June 2, 2013

Session: WSF

RF Assisted Medicine

Chair:

Hua Wang, Georgia Institute of Technology, School of ECE

Co-Chair:

Sayfe Kiaei, Arizona State University, School of Electrical, Energy and Computer Engineering

With the rapid growth of novel integrated sensors, low-power circuits/systems, and energy-efficient wireless communications, radio-frequency (RF) technology has become one of the major enabling factors for future personalized healthcare. This workshop, entitled 'RF Assisted Medicine', is designated to showcase the state-of-the-art technologies in this fast evolving area. We will cover two major and highly correlated topics in this program -- RF medically implanted sensors and wireless body area network (WBAN). The first topic focuses on providing high-performance in vivo sensing and actuation as well as information/power transmission between internal and external devices on the human body, while the second topic aims at establishing efficient wireless communications among multiple miniaturized body sensor units (BSU) and a single body central unit (BCU). The synergistic integration of the two technologies has the potential to enable a plethora of diagnostic and therapeutic applications in future medical care. In order to provide a high-quality education opportunity for the attendees while maintaining a coherent theme, we propose to organize the workshop with four following related sessions. (1) Wireless Medical Applications: Concepts and Motivations. This session will serve as a high-level review and emphasize on various applications which utilize RFIC to assist the medicine and a healthy living of the users. Topics including forward-looking roadmap, medical applications, and technologies will be covered. This talk therefore serves as an introduction for the workshop and demonstrating the big pictures of this rapidly growing field. (2) Transcutaneous Power and and Data Transmission to Implantable Microelectronic Devices. This talk will focus on how to establish the wireless link into/from inside the body (IMD). Fundamentals of efficient power and wireless data transmission into/from the body will be presented, which is a perfect example of how RF technologies are used in assisted medical applications. This wireless power and data transmission technology is also the core part of many implantable medical electronics. Moreover, design optimization procedures, using two-, three-, and four-coil resonant systems, will be discussed to achieve the highest possible power transmission efficiency. Some of the latest techniques will also be reviewed to establish wideband bidirectional communication links across the skin. (3) WBAN: Medical Applications and Challenges. This session will present how to establish energy-efficiency wireless link outside of the body based on Wireless Body Area Networks (WBANs), which is another example of how RF technologies will assist medical applications. This talk will first provide an overview of WBANs, including emerging medical applications and recent standards activity. Challenges and opportunities for WBANs systems will be discussed, including areas where current technology falls short and innovations are required in order to meet targets for reliability, security, and sensor lifetime. (4) Wireless Real-Time Monitoring of Brain Neurochemistry. This presentation will focus on a key example application of RF assisted medicine which performs chemical recording for neural engineering. The presented wireless real-time monitoring technology achieves high-Mbps data transmission over meter-range distances. The talk will first introduce neural engineering applications and describe the fundamentals of brain interfacing. Then it will showcase one example of engineered devices for real-time, concurrent sensing of neurochemical signals and electrical action potentials in mouse brains. Various design/implementation challenges due to high-site-density wireless monitoring will be highlighted, and emerging wireless communication technologies to potentially address these challenges will be discussed.

WSF-1

Wireless Medical Systems: Concepts and Applications

1300-1345

T. Denison, Brown University, Providence, United States

 

This session will serve as a high-level review and emphasize on various applications which utilize RFIC to assist the medicine and a healthy living of the users. Topics including forward-looking roadmap, medical applications, and technologies will be covered. This talk therefore serves as an introduction for the workshop and demonstrating the big pictures of this rapidly growing field.

WSF-2

Transcutaneous Power and Data Transmission to Implantable Microelectronic Devices

1345-1430

M. Ghovanloo, Georgia Institute of Technology, Atlanta, United States

 

I will cover the fundamentals of efficient power and wideband data transmission across inductive links. I will discuss the optimization procedure to achieve the highest possible power transmission efficiency using two-, three-, and four-coil resonant systems. I will review some of the latest techniques to establish wideband communication links across the skin, and touch on efficient methods to convert the received AC power to DC and stabilize it at a desired level despite coupling variations.

WSF-3

WBAN: Medical Applications and Challenges

1430-1515

D. D. Wentzloff, University of Michigan, Ann Arbor, United States

 

WBANs enable unobtrusive administration of a treatment and monitoring as patients carry on with normal activities, while at the same time improving the quality of healthcare. This talk will provide an overview of WBANs, including emerging applications and recent standards activity. Challenges and opportunities for wireless communication will be discussed, including areas where current technology falls short and innovations are required to meet targets for reliability and node lifetime.

WSF-4

Wireless Real-Time Monitoring of Brain Neurochemistry

1515-1600

P. Mohseni, Case Western Reserve University, Cleveland, United States

 

This talk will first provide an introduction to neural engineering and then showcase one example of engineered devices for real-time, concurrent sensing of neurochemical signals and electrical action potentials in the brain of small laboratory animals. Challenges in high-site-density, wireless monitoring of brain neurochemistry will be highlighted and emerging wireless communication technologies to potentially address these challenges will be discussed and showcased.

2013 BioWireless

Austin, Texas, USA

Renaissance Austin Hotel

20–23 January, 2013

Program: pdf format

2012 BioWireless

Santa Clara, California, USA

­Santa Clara Marriott

15–18 January, 2012

Program: pdf format

2012 International Microwave Symposium

 

6/20 WE2F: RF devices for wireless health care applications and biosensing

Venue : 511AD

Chair : Katia Grenier, LAAS-CNRS

Co-Chair : Yanzhu Zhao, Medtronic Inc.

Abstract : This session features latest advances in utilization of RF devices for wireless health care applications and biosensing. The talks include compact wireless implants for intraocular pressure and gastrosophageal reflux monitoring, microwave sensors for very small volume (nanoliter) liquid characterization, and the latest advances in vital sign Doppler radar for multi-subject localization.

 

WE2F-1 1010 – 1030

Simultaneous Localization and Respiration Detection of Multiple People Using Low Cost UWB Biometric Pulse Doppler Radar Sensor

Y. Wang1, Q. Liu1,2, A. E. Fathy1, 1University of Tennessee, Knoxville, United States, 2Beijing Institute of Technology, Beijing, China

In this paper, we present a low cost ultra wideband (UWB) biometric pulse Doppler radar sensor for respiration detection and monitoring applications. The developed sensor goes beyond detecting the breathing of a single person as conventional radars do; to simultaneously localizing and monitoring multiple human objects as well. The biometric sensor achieves a high range resolution of 3mm, which makes it capable of detecting very tiny motions, such as breathing and heartbeat.

WE2F-2 1030 – 1050

2-D Wireless Human Subjects Positioning System Based on Respiration Detections

Y. Su1, C. Chang1, J. Guo1, S. Chang1, 1National Chung-Cheng University, Chiayi , Taiwan, 2National Chung-Cheng University, Chiayi , Taiwan, 3Center of Advanced Institute of Manufacturing for High-tech. Innovations,National Chung-Cheng University, Chiayi , Taiwan

This paper presents a 2-D wireless positioning system for human subjects. A quadrature Doppler radar is developed to sense the presence of human subject upon the respiration signal detection, while the switched-beam phased antenna array is utilized to determine the target’s angular information. With two radars employed, the 2-D posi­tioning can be achieved based on angle of arrival (AoA) algorithm. Experiments by 2.28-GHz switched-beam radar systems have been performed for verification.

WE2F-3 1050 – 1110

Accurate Nanoliter Liquid Complex Admittance Characterization up to 40 GHz for Biomedical Ap­plications

T. Chen, D. Dubuc, K. Grenier, LAAS, Toulouse, France

In this paper is demonstrated an accurate liquid sensing technique in the nanoliter-range from 40 MHz to 40 GHz. The sensor is based on an interdigitated capacitor with a microfluidic channel placed on top to confine the liquid. Its sensing volume corresponds to 0.9 nL. Both alcohol and biological aqueous solutions have been precisely defined and distinguished in terms of capacitance and conductance’s contrasts with respect to pure water.

WE2F-4 1110 – 1130

Remote Detection of Gastroesophageal Reflux Using an Impedance and pH Sensing Transponder

H. Cao1, V. Landge1, S. Thakar1, S. Rao2, L. Hsu1, S. Tang3, S. Spechler4, H. Tibbals5, J. Chiao1, 1The University of Texas at Arlington, Arlington, United States, 2MED-WORX, Grand Prairie, United States, 3The University of Mississippi, Jackson, United States, 4The University of Texas Southwestern, Dallas, United States, 5University of Texas at Arlington, Arlington, United States

We developed a dual-sensor system to monitor the symptoms in gastroesophageal reflux disease (GERD). The system consists of an implantable transponder and an external reader. Bench-top experiments were conducted to examine the robustness of the wireless transponding system. Preliminary in vivo experiments were conducted with a live pig.

WE2F-5 1130 – 1150

A Compact-Size Packaged Third-Order Harmonic Tag for Intraocular Pressure (IOP) Monitoring inside a Mouse Eye

D. Ha1, T. Lin1, W. N. de Vries2, B. Kim1, A. L. Chlebowski1, S. W. John2, P. P. Irazoqui1, W. J. Chappell1, 1Purdue University, West Lafayette, United States, 2The Jackson Laboratory, Bar Harbor, United States

This paper presents the fabrication process of an ultrasmall size Parylene tag in which a micro-electromechanical systems (MEMS) capacitive pressure sensor is packaged with a self-expandable Nitinol antenna and a diode. From the device implanted inside the mouse eye, a resonance frequency shift of the third-order harmonic signal was detected with a sensitivity of approximately 1.5 MHz/mmHg at an 11.5 cm distance from the sensor as the pressure inside the mouse eye changed.

 

6/20 WE4G : Biomedical Sensors

Venue : 511BE

Chair : Claude Weil, NIST Boulder

Co-Chair : Arnaud Pothier, XLIM Research Institute

Abstract : Session focuses on new biosensing techniques for identifying and diagnosing cancer cells, as well as for electroporation cancer treatment. Advanced radar methods for remote monitoring of respiration are also discussed.

 

WE4G-1 1600 – 1620

Microwave Biosensors for Identifying Cancer Cell Aggresiveness Grade

L. Zhang1, C. Dalmay1, A. Pothier1, P. Blondy1, C. Bounaix Morand du Puch2, C. Laurette2, A. Lacroix3, F. Lalloue3, S. Battu3, M. Jauberteau3, 1Xlim, Limoges, France, 2Oncomedics, Limoges, France, 3Université de Limoges, Limoges, France

This paper illustrates the potential of microwave frequencies for biological purpose analysis and demonstrates that cell cancer grades can be identified using microwave characterisations. Hence, based on permittivity measure­ments on 3 colon cancer cell lines loading RF resonators, the presented results show significant electromagnetic signature differences as function analyzed cell cancer grade.This sensing methode appears very promising to de­velop new powerful tools for early cancer diagnostic.

WE4G-2 1620 – 1640

Micromachined 100GHz Near-Field Measurement Probe for High-Resolution Microwave Skin-Cancer Diagnosis

F. Töpfer, S. Dodorov, J. Oberhammer, KTH Royal Institute of Technology, Stockholm, Sweden

This paper reports on a novel millimeter-wave measurement probe for high resolution skin-cancer diagnosis. A 18times smaller tip size than conventional probes was achieved by micromachining a silicon-core tapered dielectric waveguide. Furthermore, a unique concept of micromachined test samples of tailor-made permittivity for mimick­ing tissue is presented. Fabricated probes and test samples were successfully characterized, and multiple layers emulating skin anomalies were clearly distinguishable.

WE4G-3 1640 – 1700

Characterization of a TEM Cell-based Setup for the Exposure of Biological Cell Suspensions to High-intensity Nanosecond Pulsed Electric Fields (nsPEFs)

S. Kohler1, T. Vu1, P. Vernier2,3, P. Leveque1, D. Arnaud-Cormos1, 1XLIM, Limoges, France, 2MOSIS, Los Angeles, United States, 3University of South California, Los Angeles, United States

In this paper, we propose and characterize a setup based on a Transverse ElectroMagnetic (TEM) cell to expose a Petri dish filled with a biological suspension to nanosecond high-voltage pulsed electric fields. Monopolar and bipolar pulses of 1.2 ns duration and 1.6 kV amplitude are delivered to the TEM cell. Time domain measurements and numerical results show that the system is well suited to deliver high-intensity pulsed electric fields with 1.2 ns duration and amplitudes of at least 100 kV/m.

WE4G-4 1700 – 1710

A 96 GHz Radar System for Respiration and Heart Rate Measurements

S. Ayhan1, S. Diebold1, S. Scherr1, T. Zwick1, I. Kallfass1, A. Tessmann2, O. Ambacher2, 1Karlsruhe Institute of Technol­ogy (KIT), Karlsruhe, Germany, 2Fraunhofer IAF, Freiburg, Germany

Stand-off detection of vital signs with radar based sensors is a highly promising approach for applications in the field of medical surveillance, emergency and security. A 96 GHz continuous wave (CW) radar system based on waveguide-packaged MMIC radar components is set-up for accurate determination of human chest displacements. The radar set-up is described and its boundaries and limitations are analyzed. Measurements using a person in 1 m distance are analyzed in time and frequency domain.

WE4G-5 1710 – 1720

Design of a UWB Radar System for Remote Breath Activity Monitoring

S. Pisa, E. Pittella, E. Piuzzi, M. Cavagnaro, P. Bernardi, Sapienza University of Rome, Rome, Italy

In this paper a theoretical approach has been followed for designing a ultra wideband radar for breath activity monitoring. The designed radar complies with the Federal Communication Commission emission mask and is able to discriminate among breath activity phases. This radar has been implemented by using an indirect time domain reflectometry system and tested for pulmonary function monitoring. It has been able to follow the breath activity of a subject in agreement with spirometry results.

 

6/21 TH1F : Biomedical Imaging

Venue : 511AD

Chair : Abbas Omar, University of Magdeburg

Co-Chair : Shahed Reza, Raytheon

 

Abstract : The session considers latest advances in both microwave and magnetic-resonance imaging for biomedical applications. In microwave imaging, processing of the received signal for improving image construction is emphasized. The focus of the MRI section is the optimization of microwave coils and computation of SAR

 

TH1F-1 0800 – 0820

Time-Domain Microwave Cancer Screening: Optimized Pulse Shaping Applied to Realistically Shaped Breast Phantoms

E. Porter, A. Santorelli, S. A. Winkler, M. Coates, M. Popović, McGill University, Montreal, Canada

We compare the tumor detection ability of a time-domain microwave radar system for breast cancer screening fed with two different pulses. We conduct measurements on breast phantoms using as inputs to our system both a ge­neric pulse and a pulse reshaped with a synthesized broadband reflector (SBR) designed to have an advantageous frequency profile. Our results in both time and frequency domains demonstrate that this pulse shaping technique improves the tumor response and system efficiency.

TH1F-2 0820 – 0840

Terahertz Imaging for Margin Assessment of Breast Cancer Tumors

A. M. Hassan1, D. C. Hufnagle2, M. El-Shenawee1, G. E. Pacey3, 1University of Arkansas, Fayetteville, United States, 2Miami University, Oxford, United States, 3Ohio State University, Dayton, United States

This work presents experimental terahertz measurements of excised formalin fixed paraffin embedded (FFPE) hu­man breast cancer tissues. The data are collected using a terahertz pulsed system operating from 0.1 THz to 3THz. The results represent preliminary investigation of terahertz imaging technique for assessing the tumor margins. The direct imaging method will be compared with inverse scattering imaging methods using the experimental data along with histopathological images as references.

TH1F-3 0840 – 0900

Sensitivity-based Microwave Imaging with Raster Scanning

Y. Zhang, S. Tu, R. K. Amineh, N. K. Nikolova, McMaster University, Hamilton, Canada

A recently proposed sensitivity-based microwave imaging algorithm shows good sensitivity and resolution in nu­merical experiments. Here, the algorithm is applied with measured data from the raster scanning of tissue phan­toms. The sensors are two dielectric-filled TEM horn antennas. Images of scatterer(s) embedded in lossy tissue phantoms of thickness 5 cm are successfully obtained using the transmission coefficients acquired in the frequency range from 3 GHz to 10 GHz.

TH1F-4 0900 – 0920

RF Multi-Channel Head Coil Design with Improved B1+ Fields Uniformity for High-Field MRI Systems

S. Sohn, L. DelaBarre, J. T. Vaughan, A. Gopinath, University of Minnesota, Minneapolis, United States

In the high-fields MRI, the wavelength inside the body is short and smaller than the human anatomy. At these shorter wavelength, interference effects appear; the uniformity of the RF excitation B1+ field over the whole sub­ject becomes inhomogeneous. In this study, double trapezoid-like shape is proposed to obtain gradual impedance variation and flatten B1+ field profile along the coil length using microstrip transmission lines, the TEM coil.

TH1F-5 0920 – 0940

Computational and Experimental Studies of Orthopedic Implants Heating under MRI RF Coils

Y. Liu1, W. Kainz2, F. Shellock3, J. Chen1, 1University of Houston, Houston, United States, 2FDA, Silver Spring, United States, 3University of Southern California, Los Angeles, United States

The heating of orthopedic implants under MRI RF fields were investigated 1.5T and 3T systems. Modeling and experiments

2011 International Microwave Symposium

One focus session, three workshops and three technical oral sessions

Room: 314-315 1600 Tuesday, June 7, 2011

TU4B: Focus Session - High Field Magnetic Resonance Imaging Systems

Magnetic Resonance Imaging (MRI) is a high resolution non-ionizing (safe) tomographic technique that is extensively used for medical diagnostics and other related applications. It is based on creating two distinct energy states for the quantum spin of hydrogen nuclei in water molecules using a very strong static magnetic field. Better image resolution and higher tissue contrast can be achieved by increasing the strength of the static magnetic field. This Focus Session will provide a forum for discussions of some aspects of high field MRI systems including switching instrumentation, use of antennas to create the RF magnetic fields in the human body, the signal processing of MRI signals for images, and surgical techniques with MRI monitoring.

 

WFD: Medical and Biological Microwave Sensors and Systems

Friday, 10 June 2011

Due to rapid advances in integrated circuit technology and wireless communications, that enabled inexpensive radio and digital signal processing implementations, microwave technology has become readily available for use in medicine and biology. This workshop will include state-of-the-art applications of RF, microwave, and millimeter wave technology in medicine and biology. These applications include modern MRI imaging, tracking for surgical navigation and monitoring of endangered species, physiological monitoring and treatment, communications and powering for implantable devices, and control of cellular processes using millimeter-waves.

 

WMG: Recent Developments in Microwave Imaging and Detection

Friday, 10 June 2011

Microwaves have been used successfully for target detection and for imaging of dielectric bodies where relatively long wavelength allows for penetration into optically opaque materials such as living tissue, clothing, wood, ceramics, concrete, soil, etc. The possibility of using the ultra-wide band from 3.1 GHz to 10.6 GHz and the advent of a new generation of high-speed oscilloscopes and waveform generators spurred a new wave of activity in short-range applications such as biomedical imaging, through-wall imaging, concealed weapon detection, and non-destructive testing. This workshop aims at bringing together researchers and designers involved in near- to medium-range imaging and detection using microwaves.

 

WMF: Challenges and Techniques of Magnetic Resonance Imaging (MRI) Systems

Friday, 10 June 2011

The workshop offers the MTT community members, who have not been involved in MRI before, an outstanding opportunity to understand its concept and to contribute with their expertise to the improvement and optimization of high-field MRI systems. Better image resolution and higher tissue contrast are achieved by increasing the strength of the static magnetic field B0. Scanners with B0 > 4T (fL > 160MHz) are categorized as “High Field”. Only those analytical and numerical techniques developed by the MTT community are capable of characterizing and optimizing such structures. The tutorial will present material covering the RF design practice used in Magnetic Resonance Scanners with a focus on circuit design issues involved in developing components used within the high magnetic field encountered in the bore of the MRI magnet.

Room: 314-315 0800 Tuesday, June 7, 2011

Session: TU1B, RF and Microwaves in Medicine: Monitoring and Imaging

Chair: J.-C. Chiao, University of Texas at Arlington

Co-Chair: Arye Rosen, Drexel University

This session focuses on present developments of Doppler radar to monitor vital signs, and novel designs and tuning of high-field magnetic resonance imaging (MRI) coils for noninvasive diagnosis. 

   

TU1B-1

Two-Dimensional Noncontact Vital Sign Detection using Doppler Radar Array Approach

0800-0820

X. Yu1, C. Li2, J. Lin1, 1University of Florida, Gainesville, United States, 2Texas Tech University, Lubbock, United States

 

A Doppler radar array is developed for two-dimensional noncontact vital sign detection. Using the radar array, cancellation of the noise from planar random walk of human body is achieved. The radar array also strengthens the detecting sensitivity on the respiration and heartbeat and its principle is discussed. A DC offset compensation algorithm is introduced to free the body movement cancellation from disturbance of unwanted DC offset. Experiments were performed with a human subject in the lab.

 

 

TU1B-2

Modeling of Human Torso Time-Space Characteristics for Respiratory Effective RCS Measurements with Doppler Radar

0820-0840

J. E. Kiriazi, O. Boric-Lubecke, V. M. Lubecke, University of Hawaii at Manoa, Honolulu, United States

 

This paper demonstrates a theoretical model for the torso time-space characteristics by formulating the baseband signal of a CW Doppler radar system as a superposition of two components, one from the thorax and the other from the abdomen. Measurements of a female subject in a supine position are used for verification. By reproducing the measured baseband signal, the respiration parameters could be identified for the subject under test.

 

 

TU1B-3

Combination of Travelling Wave Approach and Microstrip Transceiver Coil Arrays for MRI at 7T

0840-0900

I. A. Elabyad1, T. Herrmann2, J. Bernarding2, A. Omar1, 1University of Magdeburg, Magdeburg, Germany, 2University of Magdeburg, Magdeburg, Germany

 

To homogenize the B1+ field and decrease SAR for MRI at 7T, more degrees of freedom are needed and different excitation approaches are required. Microstrip array is a promising approach for excitation and reception at 7T. Travelling wave is another approach for excitation based on propagating modes excited from an antenna. A combination of the two excitation approaches is presented. Results indicate that such a combination can increase the B1+ field homogeneity and decrease SAR at 7T.

 

 

TU1B-4

An Investigation of Alternating Impedance Microstrip Transceiver Coil Arrays for MRI at 7T

0900-0920

I. A. Elabyad, A. Omar, University of Magdeburg, Magdeburg, Germany

 

The magnetic field generated by a conventional MSR is inhomogeneous along the resonator axis. It is strong at the center and weak at the terminating ends. To homogenize the B1+ field, it is required to modify the traditional MSR. Recently, an approach based on alternating impedance MSR has been presented. Another configuration of alternating impedance MSR is proposed. Results indicate that, the alternating impedance MSR with circular elements is the best coil in terms of B1+ field homogeneity.

 

 

TU1B-5

Auto-tuning of the RF Transmission Line Coil for High-Field Magnetic Resonance Imaging (MRI) Systems

0920-0940

S. Sohn, J. Vaughan, A. Gopinath, University of Minnesota, Minneapolis, United States

 

RF coil with microstip transmission line have been used for high-fields magnetic resonance imaging (MRI). These coil elements have narrow bandwidth due to its high quality factors (Qs). Although high signal-to-noise ratio (SNR) of RF coils is obtained from this property it has a critical drawback, loading (body) effect. In this study, an adaptive impedance matching technique for 7 Tesla MRI systems is proposed to avoid mismatch of the RF loaded coils at the Larmor frequency (297MHz).

Room: 314-315           1000 Tuesday, June 7, 2011

Session: TU2B, RF and Microwaves in Medicine: Medical Sensors and Devices

Chair: Natalia Nikolova, McMaster University

Co-Chair: Anand Gopinath, University of Minnesota

This session focuses on recent advances in wireless technology utilized for medical implants and wearable devices in clinical applications for diagnosis and prognosis.

 

TU2B-1

Digital Microwave System for Monitoring Intracranial Pressure in Hydrocephalic and Traumatic Brain Injury Patients

1000-1020

X. Meng1, M. R. Tofighi2, A. Rosen1, 1Drexel University, Philadelphia, United States, 2Pennsylvania State University, Middletown, United States

 

The monitoring of acute and later stages of changes of intracranial pressure (ICP) is important in studies of the effects of hydrocephalus and traumatic brain injury. A digital prototype for wireless ICP measurement based on Texas Instrument’s CC2500 2.4 GHz transceiver and MSP430 ultra-low-power microcontroller has been designed, investigated, and tested. In-vitro evaluations under different circumstances are described to demonstrate the repeatability, stability, and reliability of the device.

 

 

TU2B-2

A Miniature Power-Efficient Bidirectional Telemetric Platform for in-vivo Acquisition of Electrophysiological Signals

1020-1040

A. Farajidavar1, P. G. McCorkle1, T. W. Wiggins1, S. M. Rao1, C. E. Hagains1, Y. B. Peng1, J. L. Seifert1, M. I. Romero1, G. O'Grady2, L. K. Cheng2, S. Sparagana3,4, M. R. Delgado3,4, S. Tang5, T. Abell5, J. Chiao1, 1University of Texas at Arlington, Arlington, United States, 2The University of Auckland, Auckland, New Zealand, 3Texas Scottish Rite Hospital for Children in Dallas, Dallas, United States, 4University of Texas Southwestern Medical Center, Dallas, United States, 5University of Mississippi Medical Center, Jackson, United States

 

The need for in vivo wireless acquisition of biological signals is emerging in various medical fields. Electrophysiological applications including recording gastric electrical activity (GEA), electrocorticography (ECoG), and transcranical motor evoked potentials (TcMEP) require physically miniaturized devices with low power consumption and capability of implantation. We have developed three telemetric systems for GEA, ECoG and TcMEP applications based on a common transceiver platform.

 

 

TU2B-3

Ultra-thin Tag Fabrication and Sensing Technique using Third Harmonic for Implantable Wireless Sensors

1040-1100

T. Lin1, D. Ha1, W. N. de Vries2, B. Kim1, A. L. Chlebowski1, S. W. John2, P. P. Irazoqui3, W. J. Chappell1, 1Purdue University, West Lafayette, United States, 2Jackson Laboratory, Bar Harbor, United States

 

This paper presents the fabrication of an ultra-thin tag for identification and sensing applications in extremely small implantable regions. Particularly, we are demonstrating the capability to create a telemetry system which is implantable in a mouse eye. This system will eventually be able to monitor intraocular pressure (IOP). Telemetry with a small tag implanted inside of the eye is established for the first time using the 3rd order harmonic response from the implanted device.

 

 

TU2B-4

A Wireless Strain Sensor System for Bladder Volume Monitoring

1100-1120

H. Cao1, S. K. Thakar1, T. Fu2, M. Sheth1, M. L. Oseng1, V. Landge1, Y. Seo1, J. Chiao1, 1The University of Texas at Arlington, Arlington, United States, 2Centennial High School, Frisco, United States

 

A wireless IDC strain sensor system has been designed to monitor the bladder volume in patients who suffer from urinary incontinence. A proof-of-concept passive telemetry platform was developed to employ the sensor in vivo and a commercial wireless module was utilized for networking and data recording. The sensor was calibrated with a cantilever beam and the entire system was tested with a bladder phantom model.

 

 

TU2B-5

Untethered Helmet Mounted functional Near Infrared (fNIR) Biomedical Imaging?

1120-1140

K. Manseta1, A. M. Khwaja1, E. Sultan1, P. Daruwalla1, K. Pourrezaei1, L. Najafizadeh2, A. Gandjbakhche2, A. Daryoush1, 1Drexel University, Philadelphia, United States, 2National Institutes of Health, Bethesda, United States

 

Broadband (30-1000 MHz) frequency-modulated spectroscopic measurements of brain tissue using near IR wavelengths are used for accurate extraction of absorption and scattering coefficients of cortex, CSF, and skull. Design of a helmet mounted untethered fNIR system is presented which provides wireless communication between the monitoring and helmet mounted fNIR imaging sensors using a high speed wireless ISM band transmitter and UWB communication standards.

Room: 314-315           1420 Tuesday, June 7, 2011

Session: TU3B, Measurement Techniques for Biological Tissues and Subjects

Chair: Mohammad-Reza Tofighi, Pennsylvania State University, Harrisburg

Co-Chair: J-.C. Chiao, University of Texas at Arlington

This session covers a range of novel measurement techniques for characterization of biological subjects, and interfacing tissues with high frequency or short pulse signals.

TU3B-1

Image Quality Enhancement in the Microwave Raster Scanning Method

1420-1440

A. Khalatpour, R. K. Amineh, H. Xu, Y. Baskharoun, N. K. Nikolova, McMaster University, Hamilton, Canada

 

We propose signal processing algorithms to improve the quality of the images obtained with microwave raster scanning measurements. These algorithms include: (1) blind deconvolution and (2) microwave holography. The first algorithm removes the integration effect of the antenna aperture using complex-valued blind deconvolution. The second algorithm implements near-field microwave holographic imaging applied to the data already processed by the first algorithm.

 

 

TU3B-2

Sensor Array Based on Split Ring Resonators for Analysis of Organic Tissues

1440-1500

M. Puentes, C. Weiß, M. Schüßler, R. Jakoby, Technische Universität Darmstadt, Darmstadt, Germany

 

A sensor array concept has been developed using microstrip-line-excited split-ring resonators (SRRs). With this structure it is possible to spatially resolve the dielectric properties of a Material Under Test (MUT). The SRRs are designed to have different resonant frequencies and are decoupled from each other to indicate the dielectric properties of the MUT and its location within the array. Several prototype sensors have been realized and tested to prove the concept.

 

 

TU3B-3

Coplanar Waveguide with Defected Ground Structure for Nanosecond Subcellular Electroporation

1500-1520

C. Palego1, S. Halder1, J. C. Hwang1, C. Merla2, M. Liberti2, F. Apollonio2, A. Paffi2, 1Lehigh University, Bethlehem, United States, 2La Italian Inter-University Centre for the Study of Electromagnetic Fields and BioSystems , Rome, Italy

 

A compact test structure and setup for ns-electroporation of biological cells is described. A CPW with defected ground assures impedance match with low dispersion or parasitic. The defected ground forms a microchamber for quick cell manipulation. The measured results along with EM analysis show that a 1-ns 0.1-V transmembrane potential can be induced. Although this is below the threshold for electroporation, it can be increased by using pulses with 1-ns and 10-, or 10-ns and 3-times higher amplitude.

 

 

TU3B-4

W-band Millimeter Wave Exposure System for Studying Non-thermal Effects on Skeletal Muscle Contraction

1520-1540

J. Yoon1, S. Luongo3, R. Wiese2, P. Mastin3, L. Sadovnik3, G. L. Craviso2, I. Chatterjee1, 1University of Nevada, Reno, Reno, United States, 2University of Nevada, Reno, Reno, United States, 3Sierra Nevada Corporation, Sparks, United States

 

A novel W-band (75-110 GHz) exposure system was designed, characterized and tested to be used for identifying millimeter wave (mmW) exposure parameters (frequency, modulation schemes and electric field magnitude) that could accelerate recovery from fatigue in skeletal muscle. The system allows electrical stimulation of muscle and measurement of contractile force during mmW exposure. Design and characterization of the exposure system were performed using the Finite-difference Time-Domain method and experimental measurements.

2010 International Microwave Symposium

 

Two oral technical sessions were held on Wednesday May 26 2010

 

Session: WE2D, RF and Microwave in Medicine: Medical Sensors and Devices

Chair: Mohammad-Reza Tofighi, Penn State University

Co-Chair: Natalia K. Nikolava, McMaster University

Abstract: This session presents recent developments of sensors and RF devices for medical instrumentation

•   An Implantable Batteryless Wireless Impedance Sensor for Gastroesophageal Reflux Diagnosis

T. Ativanichayaphong1, S. Tang2, L. Hsu1, W. Huang1, Y. Seo1, H. F. Tibbals4, S. J. Spechler3, J. C. Chiao1, 1University of Texas at Arlington, Arlington, United States, 2Trinity Mother Frances Hospitals and Clinics, Tyler, United States, 3University of Texas Southwestern Medical Center, Dallas, United States, 4University of Texas Southwestern Medical Center, Dallas, United States

•   3D Packaging Technique on Liquid Crystal Polymer (LCP) for Miniature Wireless Biomedical Sensor

D. Ha, B. Kim, T. Lin, Y. Ouyang, P. P. Irazoqui, W. J. Chappell, Purdue University, West Lafayette, United States

•   An Ultrasensitive CMOS Magnetic Biosensor Array with Correlated Double Counting Noise Suppression

H. Wang, S. Kosai, C. Sideris, A. Hajimiri, California Institute of Technology, Pasadena, United States

•   Microwave Sensors for Stem Cell Identification and Discrimination

C. Dalmay1, A. Pothier1, M. Cheray2, F. Lalloué2, M. Jauberteau2, P. Blondy1, 1XLIM – UMR 6172 Université de Limoges/CNRS, Limoges, France, 2Homéostasie Cellulaire et Pathologies – EA 3842 Université de Limoges, Limoges, France

•   A Novel Zigbee- based Low- cost, Low- Power Wireless EKG system

V. Mukala, V. Lakafosis, A. Traille, M. M. Tentzeris, GEDC, Atlanta, United States

•   Substrate Integrated Resonant Near-Field Sensor for Material Characterization

M. Ambrozkiewicz, A. F. Jacob, Hamburg University of Technology, Hamburg, Germany

 

Session: WE3D, RF and Microwave in Medicine: Imaging and Monitoring

Chair: J-C. Chiao, University of Texas at Arlington

Co-Chair: Arye Rosen , Drexel University

Abstract: Electromagnetic interaction with tissues and organs provides non-invasive diagnostic capability,n and high frequency wireless communication allows remote sensing of vital signs. This session presents recent development of imaging and monitoring techniques.

•   A Method to Control Non-uniformity RF $B_1$ Field for High Field Magnetic Resonance Imaging

H. Yoo1, A. Gopinath1, T. Vaughan2, 1University of Minnesota, Minneapolis, United States, 2University of Minnesota, Minneapolis, United States

•   Alternating Impedance Multi-Channel Transmission Line Resonators for High Field Magnetic Resonance Imaging

C. E. Akgun1, L. DelaBarre1, C. J. Snyder1, S. Sohn2, G. Adriany1, K. Ugurbil1, A. Gopinath2, J. T. Vaughan1, 1University of Minnesota, Minneapoilis, United States, 2University of Minnesota, Minneapolis, United States

•   Near-Field Microwave Imaging Based on Planar Aperture Scanning

R. Khalaj Amineh, M. Ravan, A. Trehan, N. K. Nikolova, McMaster University, Hamilton, Canada

•   A Fast Clutter Cancellation Method in Quadrature Doppler Radar for Noncontact Vital Signal Detection

T. Chin, K. Lin, S. Chang, C. Chang, National Chung Cheng Univ., Ming-Hsiung Chia-Yi, Taiwan

•   An Injection-Locked Detector for Concurrent Spectrum and Vital Sign Sensing

F. Wang1, C. Li1, C. Hsiao1, T. Horng1, J. Lin2, K. Peng3, J. Jau4, J. Li4, C. Chen4, 1National Sun Yat-Sen University, Kaohsiung, Taiwan, 2University of Florida, Gainesville, United States, 3National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan, 4Industrial Technology Research Institute, Hsinchu, Taiwan

•   A Wire Patch Cell for "in vitro" Exposure at the Wi-Fi Frequencies

Paffi1, F. Apollonio1, M. Liberti1, G. A. Lovisolo2, R. Lodato2, S. Mancini2, S. Chicarella1, G. d'Inzeo1, C. Merla3, 1ICEmB at , Rome, Italy, 2ICEmB at RC Casaccia ENEA, Rome, Italy, 3CNRS-University of Limoges, Limoges, France

2009 Radio and Wireless Symposium

A focus session (MO4A) on Biomedical Applications of RF/Microwave Technologies was held on January 19, 2009.

Chair: Victor Lubecke, University of Hawaii

Co-chair: Mohammad-Reza Tofighi, Penn State University

 

The speakers that were present at the sessions and the titles of their topics are as follows:

·     Embedded Microwave System for Monitoring of Intracranial Pressure

U. Kawoos11, R. Warty11, M. Tofighi22, F. A. Kralick33, D. Yoo4, T. Neal5, and  A. Rosen11, 11Drexel University, Philadelphia, United States, 2Penn State University, Middletown, United States, 3Drexel University College of Medicine, Philadelphia, United States ,4 Army Programs Directorate, The MITRE Corporation, Eatontown, NJ, Unites States,  5Healthcare Mission Area, The MITRE Corporation, McLean, VA, United States

·     Capsule Antennas for Medication Compliance Monitoring

R. Bashirullah11, N. Euliano22, 1University of Florida, Gainesville, United States, 2Convergent Engineering, Gainesville, United States

·     Modeling and Design of a Wireless Hearing Aid Communication System

G. S. Shaker1, M. Nezhad-Ahmadi2, S. Safavi-Naeini1, G. Weale2, 1University of Waterloo, Waterloo, Canada, 2AMI Semiconductor Canada Co, Waterloo, Canada

·     RFID-Enabled Biosensing Wireless Modules

M. M. Tentzeris1, A. Traille1,2,L. Yang1, V. Lakafossis1, R. Vyas1, A. Rida1, A. Haque1, D. Staiculescu1, 1Georgia Institute of Technology, Atlanta, United States, 2Georgia Institute of Technology, Smyrna, United States

·     Wireless Technologies in Sleep Monitoring

V. Lubecke1,2, O. Boric-Lubecke1,2, 1University of Hawaii, Honolulu, United States, 2Kai Sensors, Honolulu, United States

2009 International Microwave Symposium

A technical session (TH4C) on Biomedical Effects and Medical Applications: Imaging, was held on June 11, 2009.

Chair: Anand Gopinath, University of Minnesota

Co-chair: Gerald R. DeJean, Microsoft Corporation

 

The speakers that were present at the sessions and the titles of their topics are as follows:

·     Novel Multi-Channel Transmission Line Coil for High Field Magnetic Resonance Imaging

C. E. Akgun1, L. DelaBarre1, S. Sohn2, C. J. Snyder1, G. Adriany1, K. Ugurbil1, J. T. Vaughan1, A. Gopinath2, 1University of Minnesota Medical School, Minneapolis, United States, 2University of Minnesota, Minneapolis, United States

·     Design and Implementation of a Quadrature RF Volume Coil for In-Vivo MR Brain Imaging of Rhesus Macaques Monkey in a Stereotaxic Head Frame

C. A. Roopnariane1, P. A. Miller2, B. S. Park2, L. Ansel2, S. Oh2, C. Lieu3, T. Subramanian3, M. Tofighi1, C. M. Collins2, 1Penn State University, Middletown, United States, 2Penn State University, Hershey, United States, 3Penn State University, Hershey, United States

·     Ultra-Wideband Antennas for Combined Magnetic Resonance Imaging and UWB Radar Applications

U. Schwarz1, F. Thiel2, F. Seifert2, R. Stephan1, M. Hein1, 1Ilmenau University of Technology, Ilmenau, Germany, 2Physikalisch-Technische Bundesanstalt, Berlin, Germany

·     Microwave Imaging of the Knee: Application to Ligaments and Tendons

S. M. Salvador1, E. C. Fear2, M. Okoniewski2, J. R. Matyas3, 1Politecnico di Torino, Torino, Italy, 2University of Calgary, Calgary, Canada, 3University of Calgary, Calgary, Canada

·     Accuracy Evaluation of Time Domain Measurement Systems for Microwave Tomography

X. Zeng1, A. Fhager1, P. Linner2, M. Persson1, H. Zirath2, 1Chalmers Univ. of Technology, Gothenburg, Sweden, 2Chalmers Univ. of Technology, Gothenburg, Sweden

·     Variation of Cole-Cole Model Parameters with the Complex Permittivity of Biological Tissues

T. M. Said, V. V. Varadan, University of Arkansas, Fayetteville, United States

 

2008 International Microwave Symposium

A technical session (TH3D) on Biomedical Effects and Medical Applications was held on June 19, 2008.

Chair: Mohammad-Reza Tofighi, Penn State University

Co-chair: Arye Rosen, Drexel University

The speakers that were present at the sessions and the titles of their topics are as follows:

·     On Design of a Low Power wireless Hearing Aid Communication System

G. S. Shaker1, M. Nezhad-Ahmadi2, S. Safavi- Naeini1, G. Weale2 ,1University of Waterloo, Waterloo, Canada, 2AMI Semiconductor Canada Co., Waterloo, Canada

·     Electrical Properties of Nude Rat Skin and Design of Implantable Antennas for Wireless Data Telemetry

T. Karacolak, E. Topsakal,  Mississippi State University, Mississippi State, United States

·     Label Free Biosensors for Human Cell Characterization using Radio and Microwave Frequencies

C. Dalmay, A. Pothier, P.Blondy, F.Lalloue, M.Jauberteau, Limoges University, Limoges, France

·     High Frequency Wideband Permittivity Measurements of Biological Substances Using Coplanar Waveguides and Application to Cell Suspensions

S. Seo1, T. Stintzing1, I. Block2, D. Pavlidis1, M. Rieke1, P. G. Layer1, 1Darmstadt University of  Technology, Darmstadt, Germany, 2University of Illinois at Urbana-Champaign, Urbana, United States

·     Two frequency Radar Sensor for Non-contact Vital Signal Monitor

J. Oum1, D. Kim2, S. Hong1, 1Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea, 2Chungnam National University, Daejeon , Republic of Korea

·     A Novel Liquid Antenna for Wearable Bio-monitoring Applications

Traille, L. Yang, A. Rida, M. M. Tentzeris, Georgia Institute of Technology, Atlanta, United States

Workshop (WSF) on Medical Applications of RF and microwave was held on June 15, 2008.

Organizers:

Edward C. Niehenke, Niehenke Consulting,

Ayre Rosen, Drexel University,

Roger Kaul, Army Research Laboratory.

Abstract:

RF and Microwave technologies play a key role today in medical applications. This full-day workshop presented a broad range of the latest applications of this technology in this rapidly developing field with emphasis on newer emerging diagnostic and therapeutic techniques. Focused areas include imaging, diagnostics, therapy, and healthcare management. Key technology that was reported in the area included Cancer treatment with indirect RF/microwaves; Multi-megawatts of microwave power converted to high energy electrons, ions, plasma, and X-rays for cancer treatment; State-of-the-art thermal tumor ablation; Catheter-based systems for biological stents; Microwave  balloon systems; Electromagnetic and thermal simulation; Thermal limitations of MRI; Cardiac arrhythmia treatment; Microwave imaging; Radiometric sensing of vital sign sensing utilizing radar principle; and Microwave-communications in the management

of healthcare. The workshop will conclude with an hour long panel session in which all the speakers will address and discuss specific written questions from the workshop attendees.

Topics and Speakers

The speakers that were present at the sessions and the titles of their topics are as follows:

·        Status and Future of Medical Applications of RF and Microwave Power

Dr. Eiji Tanabe, AET Inc.

·        Medical Applications for Radiometric Sensing

Kenneth L. Carr, Meridian Medical Systems,

·        Electromagnetic and Thermal Simulations in Bio-medical Applications,

Martin H. Vogel, Ansoft Corporation

·        Non-Contact Assessment of Patient Cardiopulmonary Activity

Victor Lubecke, University of Hawaii at Manoa

·        Creation of Biological Stents and Occlusions with Microwave Catheters

Fred Sterzer, MMTC, Inc.

·        Recent Advanced in RF and Microwave Applicators for Cancer Therapy

Paul Stauffer, Duke University Medical Center

·        R&D and Standard of Wireless Body Area Network (WBAN)

Ryuji Kohno, Yokohama National University, Division of Physics

·        Tissue Ablation using RF and Microwaves - Application to Treatment of Cancer and Cardiac Arrhythmia

Dieter Haemmerich, Medical University of South Carolina, Div. Pediatric Cardiology

·        Microwave Imaging for Breast Cancer Detection

Elsie Fear, University of Calgary

 

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